C. Andrew Frank

Mitochondrial Complex I and ROS control neuromuscular function through opposing pre- and postsynaptic mechanisms

This study shows that mitochondrial Complex I depletion in Drosophila neuromuscular junctions leads to opposing effects on pre- and postsynaptic function through ROS-dependent mechanisms.

Upregulation of FasII underlies synergistic neuropathological and behavioral defects in a Drosophila model of myotonic dystrophy

This study identifies FasII upregulation as a key factor in DM1 neuropathology using a Drosophila model, showing that manipulating FasII isoforms can rescue synaptic and behavioral defects.

Arf GAP containing dAsap regulates NMJ organization and synaptic calcium through Arf6-dependent signaling in Drosophila

This study identifies dAsap as a regulator of NMJ morphology and synaptic calcium homeostasis in Drosophila through Arf6-dependent signaling.

The calcineurin regulator Sarah enables distinct forms of homeostatic plasticity at the Drosophila neuromuscular junction

The paper investigates the role of the calcineurin regulator Sarah in presynaptic homeostatic plasticity at the Drosophila neuromuscular junction, finding that dysregulation of Sarah blocks plasticity and that calcineurin activity is critical for its expression.

Roles for Mitochondrial Complex I subunits in regulating synaptic transmission and growth

This study identifies Mitochondrial Complex I subunits as regulators of synaptic transmission and growth in Drosophila, with implications for human neurological disorders.

Homeostatic depression shows heightened sensitivity to synaptic calcium

The paper investigates presynaptic homeostatic depression (PHD) at the Drosophila NMJ and finds that calcium levels are critical for its function.

Maintenance of homeostatic plasticity at the Drosophila neuromuscular junction requires continuous IP3-directed signaling

The paper shows that homeostatic plasticity at the Drosophila NMJ has distinct induction and maintenance phases, with IP3-directed signaling specifically required for maintenance.

Drosophila CaV2 Channels Harboring Human Migraine Mutations Cause Synapse Hyperexcitability That Can Be Suppressed By Inhibition Of A Ca2+ Store Release Pathway

This study introduces Drosophila models with human migraine mutations in CaV2 channels, showing hyperexcitability that can be suppressed by inhibiting intracellular Ca2+ release.

Synaptic homeostasis at the Drosophila neuromuscular junction is a reversible signaling process that is sensitive to high temperature

The paper demonstrates that synaptic homeostatic potentiation at the Drosophila neuromuscular junction is reversible and sensitive to temperature.

Conserved properties of Drosophila Insomniac link sleep regulation and synaptic function

This study shows that Drosophila Insomniac and its mammalian orthologs are functionally conserved in sleep regulation and synaptic function through an evolutionarily conserved ubiquitination pathway.