TOMM40 '523' genotype induces sex- and tissue- specific differences in cholesterol and triglyceride levels in an APOE-TOMM40 humanized mouse model
Neil Victor Yang, Dellila Hodgson, Timothy M Jang, Justin Kim, William Kirby Gottschalk, Hussein N. Yassine, Ornit Chiba‐Falek, Ronald M. Krauss
The paper investigates how TOMM40 523 poly-T variants affect lipid levels and AD biomarkers in a humanized mouse model, finding sex- and tissue-specific differences.
bioRxiv · Jun 10, 2026 · PreprintGenetics