Ronald M. Krauss

The paper investigates how TOMM40 523 poly-T variants affect lipid levels and AD biomarkers in a humanized mouse model, finding sex- and tissue-specific differences.

This study shows that TOMM40 suppression leads to cholesterol imbalance and AD-like molecular and behavioral changes in mice and human neurons.

This study shows that TMEM55B loss disrupts lipid metabolism by altering lipophagy and mitochondrial function, worsening MASLD in mice.

This study shows that TOMM40 knockdown in macrophages inhibits NLRP3 activation and increases LXR-β mediated cholesterol transporter gene expression, potentially reducing atherogenesis.

This study identifies MIR192 as a regulator of GLP-1 receptor expression, showing it improves statin-induced impairment of insulin secretion.

The paper identifies ZNF335 as a gene modulating statin response by analyzing cell line transcriptomics and mouse models.

The paper identifies genetic drivers of plasma lipoproteins in mice and links them to human lipid traits using QTL analysis and GWAS integration.

This study conducts a trans-ancestry GWAS using chronic ALT elevation as a proxy for NAFLD, identifies 77 significant loci, and validates 17 SNPs with histology and imaging data, revealing genetic links to metabolic and inflammatory traits.