Neil Victor Yang

TOMM40 '523' genotype induces sex- and tissue- specific differences in cholesterol and triglyceride levels in an APOE-TOMM40 humanized mouse model

The paper investigates how TOMM40 523 poly-T variants affect lipid levels and AD biomarkers in a humanized mouse model, finding sex- and tissue-specific differences.

TOMM40 suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer's disease

This study shows that TOMM40 suppression leads to cholesterol imbalance and AD-like molecular and behavioral changes in mice and human neurons.

Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function

This study shows that TMEM55B loss disrupts lipid metabolism by altering lipophagy and mitochondrial function, worsening MASLD in mice.

TOMM40 Knockdown in Macrophages Inhibits Oxidized LDL-induced NLRP3 Activation and Promotes LXR-β Mediated Cholesterol Transporter Gene Expression

This study shows that TOMM40 knockdown in macrophages inhibits NLRP3 activation and increases LXR-β mediated cholesterol transporter gene expression, potentially reducing atherogenesis.

TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathway

This study shows that TOMM40 regulates lipid metabolism in hepatocytes through an LXR-dependent pathway, affecting plasma lipid levels and hepatic lipid droplet accumulation.

Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response

The paper identifies ZNF335 as a gene modulating statin response by analyzing cell line transcriptomics and mouse models.