Hussein N. Yassine

ApoE isoforms establish distinct antioxidant trajectories across the aging brain

This study shows ApoE isoforms influence antioxidant pathways differently across aging, with ApoE4 showing stronger transcriptional responses but less effective protein production, linking to neurodegenerative risk.

TOMM40 '523' genotype induces sex- and tissue- specific differences in cholesterol and triglyceride levels in an APOE-TOMM40 humanized mouse model

The paper investigates how TOMM40 523 poly-T variants affect lipid levels and AD biomarkers in a humanized mouse model, finding sex- and tissue-specific differences.

TOMM40 suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer's disease

This study shows that TOMM40 suppression leads to cholesterol imbalance and AD-like molecular and behavioral changes in mice and human neurons.

Evidence for cPLA2 activation in Alzheimer's Disease Synaptic Pathology

This study shows cPLA2 overactivation is linked to synaptic loss and cognitive decline in Alzheimer's disease through increased eicosanoids and altered synaptic marker interactions.

Development of Potent, Selective cPLA2 Inhibitors for Targeting Neuroinflammation in Alzheimer's Disease and Other Neurodegenerative Disorders

This study identifies a potent cPLA2 inhibitor, BRI-50460, that modulates neuroinflammation and lipid homeostasis in Alzheimer's disease models.

Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer's disease biomarkers

The paper examines apoE glycosylation in CSF and plasma samples from ADNI, finding reduced glycosylation in MCI and progressors, and associations with AD biomarkers like t-tau, p-tau181, and Aβ1-42.

Microglia States are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease

This study identifies microglia as key contributors to senescence in Alzheimer's disease, linking cholesterol dysregulation to senescence pathologies through transcriptomic analysis of multiple datasets.