Nemo-like kinase regulates Progranulin levels in the brain through the microglial endocytosis-lysosomal pathway
Tingting Dong, Hiroshi Kokubu, Terri M. Driessen, Leon Tejwani, Janghoo Lim
This study identifies Nemo-like kinase (Nlk) as a regulator of Progranulin (PGRN) levels in the brain through the microglial endocytosis-lysosomal pathway, linking Nlk to PGRN-associated neurodegenerative diseases.
bioRxiv · Jun 28, 2018 · PreprintNeuroscience