Author

Hiroshi Kokubu

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Janghoo LimiD· 2 shared Leon TejwaniiD· 2 shared Armand SorianoiD· 1 shared Benjamin Sanders· 1 shared Chang‐Woo LeeiD· 1 shared Clara LiaoiD· 1 shared Frank RigoiD· 1 shared Hannah J. RoiD· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Janghoo LimORCID

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2 papers

Recent·Most cited

Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration

Leon Tejwani, Youngseob Jung, Hiroshi Kokubu, Sowmithra Sowmithra, Luhan Ni, Chang‐Woo Lee, Benjamin Sanders, Jong Seo Lee, Yangfei Xiang, Kimberly P. Luttik, Armand Soriano, Jennifer Yoon, Junhyun Park, Hannah J. Ro, Hyoungseok Ju, , Janghoo Lim

This study shows that reducing Nemo-like kinase enhances lysosome biogenesis and improves TDP-43 clearance, alleviating neurodegeneration in mouse models.

Journal of Clinical Investigation · Jun 29, 2023Peer-reviewedNeuroscience

Nemo-like kinase regulates Progranulin levels in the brain through the microglial endocytosis-lysosomal pathway

Tingting Dong, Hiroshi Kokubu, Terri M. Driessen, Leon Tejwani, Janghoo Lim

This study identifies Nemo-like kinase (Nlk) as a regulator of Progranulin (PGRN) levels in the brain through the microglial endocytosis-lysosomal pathway, linking Nlk to PGRN-associated neurodegenerative diseases.

bioRxiv · Jun 28, 2018 · PreprintNeuroscience