Leon Tejwani

This study shows lysosomal health influences myeloid cell states and immune responses, with Grn deficiency leading to lysosomal dysfunction and specific transcriptional changes in microglia.

This study uses longitudinal single-nucleus RNA sequencing to analyze transcriptional dynamics in SCA1 cerebellum, identifying early cellular changes and applying deep learning to predict disease state.

This study shows that reducing Nemo-like kinase enhances lysosome biogenesis and improves TDP-43 clearance, alleviating neurodegeneration in mouse models.

This study investigates the differential effects of Wnt-β-catenin signaling in Purkinje cells and Bergmann glia in SCA1, showing distinct cellular responses to enhanced signaling in disease models.

This study uses cortical organoids derived from patients with 16p11.2 CNV to show altered neurodevelopmental processes, including changes in organoid size, neuronal maturation, and migration.

This study identifies Nemo-like kinase (Nlk) as a regulator of Progranulin (PGRN) levels in the brain through the microglial endocytosis-lysosomal pathway, linking Nlk to PGRN-associated neurodegenerative diseases.