Author

Janghoo Lim

Yale UniversityORCID 0000-0002-5331-210XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Leon TejwaniiD· 4 shared Kimberly P. LuttikiD· 3 shared Chang‐Woo LeeiD· 2 shared Hannah J. RoiD· 2 shared Hiroshi Kokubu· 2 shared Hyoungseok JuiD· 2 shared Jennifer YooniD· 2 shared Luhan NiiD· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersNeuroscience

Leon TejwaniORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1

Leon Tejwani, Neal G. Ravindra, Chang‐Woo Lee, Yubao Cheng, Billy Nguyen, Kimberly P. Luttik, Luhan Ni, Shupei Zhang, Logan M Morrison, John T. Gionco, Yangfei Xiang, Jennifer Yoon, Hannah J. Ro, Fatema Haidery, Rosalie M. Grijalva, , Janghoo Lim

This study uses longitudinal single-nucleus RNA sequencing to analyze transcriptional dynamics in SCA1 cerebellum, identifying early cellular changes and applying deep learning to predict disease state.

Neuron · Nov 27, 2023Peer-reviewedNeuroscience

Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration

Leon Tejwani, Youngseob Jung, Hiroshi Kokubu, Sowmithra Sowmithra, Luhan Ni, Chang‐Woo Lee, Benjamin Sanders, Jong Seo Lee, Yangfei Xiang, Kimberly P. Luttik, Armand Soriano, Jennifer Yoon, Junhyun Park, Hannah J. Ro, Hyoungseok Ju, , Janghoo Lim

This study shows that reducing Nemo-like kinase enhances lysosome biogenesis and improves TDP-43 clearance, alleviating neurodegeneration in mouse models.

Journal of Clinical Investigation · Jun 29, 2023Peer-reviewedNeuroscience

Differential effects of Wnt-β-catenin signaling in Purkinje cells and Bergmann glia in SCA1

Kimberly P. Luttik, Leon Tejwani, Hyoungseok Ju, Terri M. Driessen, Cleo J. L. M. Smeets, Janghoo Lim

This study investigates the differential effects of Wnt-β-catenin signaling in Purkinje cells and Bergmann glia in SCA1, showing distinct cellular responses to enhanced signaling in disease models.

bioRxiv · Oct 21, 2021 · PreprintNeuroscience

Nemo-like kinase regulates Progranulin levels in the brain through the microglial endocytosis-lysosomal pathway

Tingting Dong, Hiroshi Kokubu, Terri M. Driessen, Leon Tejwani, Janghoo Lim

This study identifies Nemo-like kinase (Nlk) as a regulator of Progranulin (PGRN) levels in the brain through the microglial endocytosis-lysosomal pathway, linking Nlk to PGRN-associated neurodegenerative diseases.

bioRxiv · Jun 28, 2018 · PreprintNeuroscience