Understanding hepatitis B virus dynamics and the antiviral effect of interferon-alpha treatment in humanized chimeric mice
Laëtitia Canini, Yuji Ishida, Masataka Tsuge, Karina Durso-Cain, Tje Lin Chung, Chise Tateno, Alan S. Perelson, Susan L. Uprichard, Kazuaki Chayama, Harel Dahari
The paper models HBV kinetics in humanized mice treated with interferon-alpha, lamivudine, or both, revealing biphasic viral decline and distinct treatment effects on HBV DNA synthesis.
Journal of Virology · Apr 28, 2021Peer-reviewedSystems Biology