Harel Dahari

Modeling in vitro cell-to-cell spread of hepatitis C viral infection using an agent-based approach

This paper develops an agent-based model to simulate HCV cell-to-cell spread in vitro, incorporating cell proliferation, size changes, and foci merging, and shows it fits experimental data well.

Rat hepatitis E virus infection has multiphasic viral replication kinetics in vivo

This study characterizes the multiphasic viral replication kinetics of rat HEV in vivo, showing liver as the main replication site and ribavirin's partial efficacy in preventing viral rebound.

Modeling of hepatitis B virus infection spread in primary human hepatocytes

The paper models HBV infection spread in primary human hepatocytes using agent-based modeling, identifying viral kinetic patterns and estimating the efficacy of an entry inhibitor.

Multiphasic hepatitis B virus kinetic patterns in humanized chimeric mice can be explained via stochastic agent-based modeling of intracellular virion production cycles

The paper develops a stochastic agent-based model to explain multiphasic HBV kinetics in humanized mice by simulating intracellular virion production cycles.

Understanding hepatitis B virus dynamics and the antiviral effect of interferon-alpha treatment in humanized chimeric mice

The paper models HBV kinetics in humanized mice treated with interferon-alpha, lamivudine, or both, revealing biphasic viral decline and distinct treatment effects on HBV DNA synthesis.