The paper models HBV infection spread in primary human hepatocytes using agent-based modeling, identifying viral kinetic patterns and estimating the efficacy of an entry inhibitor.

4 citations

humanstatistical model

𝕏 PostBluesky

Systems BiologybioRxivPreprintJan 30, 2022

Multiphasic hepatitis B virus kinetic patterns in humanized chimeric mice can be explained via stochastic agent-based modeling of intracellular virion production cycles

Atesmachew Hailegiorgis, Yuji Ishida, Nicholson T. Collier…·Harel Dahari

The paper develops a stochastic agent-based model to explain multiphasic HBV kinetics in humanized mice by simulating intracellular virion production cycles.

DOI 10.1101/2022.01.30.478385

humanstatistical model

𝕏 PostBluesky

Systems BiologyJournal of VirologyPeer-reviewedApr 28, 2021

Understanding hepatitis B virus dynamics and the antiviral effect of interferon-alpha treatment in humanized chimeric mice

Laëtitia Canini, Yuji Ishida, Masataka Tsuge…·Harel Dahari

The paper models HBV kinetics in humanized mice treated with interferon-alpha, lamivudine, or both, revealing biphasic viral decline and distinct treatment effects on HBV DNA synthesis.

28 citations

mousestatistical model

𝕏 PostBluesky