Susan L. Uprichard

This paper develops an agent-based model to simulate HCV cell-to-cell spread in vitro, incorporating cell proliferation, size changes, and foci merging, and shows it fits experimental data well.

The paper models HBV infection spread in primary human hepatocytes using agent-based modeling, identifying viral kinetic patterns and estimating the efficacy of an entry inhibitor.

The paper develops a stochastic agent-based model to explain multiphasic HBV kinetics in humanized mice by simulating intracellular virion production cycles.

The paper models HBV kinetics in humanized mice treated with interferon-alpha, lamivudine, or both, revealing biphasic viral decline and distinct treatment effects on HBV DNA synthesis.