Tobias Loschko

Plasticity in nonsense-mediated decay and translation initiation regulate polyphenism

The paper investigates natural variation in mouth-form plasticity in Pristionchus pacificus, linking it to genetic and molecular mechanisms involving nonsense-mediated decay and alternative start codon selection.

Interspecies systems biology links bacterial metabolic pathways to nematode gene expression, behavior, and survival

This study links bacterial metabolic pathways to nematode gene expression, behavior, and survival by analyzing interactions between Pristionchus pacificus and its associated bacteria.

Developmental transcriptomics in Pristionchus reveals the logic of a plasticity gene regulatory network

The paper identifies two environmentally sensitive genes in a plasticity gene regulatory network and reveals metabolism as a shared pathway for mouth-form plasticity in Pristionchus.

Histone 4 lysine 5/12 acetylation provides a plasticity code with epigenetic memory of environmental exposure

The paper shows that histone 4 lysine 5/12 acetylation regulates developmental plasticity and epigenetic memory in nematodes by controlling switch gene expression during a critical environmental sensitivity window.

Comparative genomics and community curation further improve gene annotations in the nematode Pristionchus pacificus

The paper improves gene annotations in Pristionchus pacificus by combining comparative genomics and community curation, resulting in a higher quality gene set with improved ortholog completeness.