Christian Rödelsperger

Plasticity in nonsense-mediated decay and translation initiation regulate polyphenism

The paper investigates natural variation in mouth-form plasticity in Pristionchus pacificus, linking it to genetic and molecular mechanisms involving nonsense-mediated decay and alternative start codon selection.

Lessons learned from manual curation of thousands of gene models in the nematode Pristionchus pacificus

The paper curates gene models in Pristionchus pacificus, identifying and correcting over 7,500 gene annotations through manual curation and new transcriptome data.

Poly(UG)-tailed RNAs are involved in the control of thousands of genes predominantly in the germline in Pristionchus pacificus

The paper shows poly(UG)-tailed RNAs induce gene knockdown in Pristionchus pacificus and are abundant in germline-specific genes, with mutations affecting fertility.

Diet-derived vitamin B12 induces transgenerational inheritance of nematode predation through elevated vitellogenin provisioning

This study shows that vitamin B12 from diet induces transgenerational inheritance of predatory behavior in nematodes through increased vitellogenin provisioning.

Transposable elements drive regulatory and functional innovation of F-box genes

The paper identifies recurrent capture of transposable element domains by F-box genes across eukaryotes and shows their functional integration into host regulatory networks.

EBAX-1/ZSWIM8 destabilizes miRNAs resulting in transgenerational memory of a predatory trait

The paper shows that EBAX-1/ZSWIM8 destabilizes miRNAs, leading to transgenerational memory of a predatory trait in nematodes.

The genome assembly of Rhabditoides inermis from a complex microbial community reveals further evidence for parallel gene family expansions across multiple nematodes

Interspecies systems biology links bacterial metabolic pathways to nematode gene expression, behavior, and survival

This study links bacterial metabolic pathways to nematode gene expression, behavior, and survival by analyzing interactions between Pristionchus pacificus and its associated bacteria.

Developmental small RNA transcriptomics reveals divergent evolution of the conserved microRNA miR-100 and the let-7-complex in nematodes

The paper performs small RNA sequencing in Pristionchus pacificus to study miR-100 and the let-7-complex, finding novel miRNAs, developmental expression patterns, and alternative locus arrangements.

Influence of environmental temperature on mouth-form plasticity in Pristionchus pacificus acts through daf-11-dependent cGMP signaling

This study shows that temperature influences mouth-form plasticity in Pristionchus pacificus through daf-11-dependent cGMP signaling involving DAF-11, DAF-25, and TAX-2.

A simplified workflow for the analysis of whole-genome sequencing data from Pristionchus pacificus mutant lines

The paper presents a simplified workflow for analyzing whole-genome sequencing data from Pristionchus pacificus mutant lines, reducing candidate mutations from 3,500 to 10.

Comparative genomics and community curation further improve gene annotations in the nematode Pristionchus pacificus

The paper improves gene annotations in Pristionchus pacificus by combining comparative genomics and community curation, resulting in a higher quality gene set with improved ortholog completeness.

Conserved nuclear receptors controlling a novel trait target fast-evolving genes expressed in a single cell

The paper identifies conserved nuclear receptors that regulate fast-evolving genes involved in morphological changes in nematodes.

Differential Variant Calling In Mutants From Diverse Genetic Backgrounds: A Case Study In The Nematode Pristionchus pacificus

The paper introduces differential variant calling for mutants with diverse genetic backgrounds, identifying a splice-site mutation in P. pacificus.