Hanh Witte

Terminal selector and subtype selector function across 200 million years of nematode evolution

The paper compares terminal and subtype selectors in two nematode species to study neuronal evolution over 200 million years, finding conservation and novelty in regulatory programs.

A multifunctional polyketide synthase in nematodes produces divergent families of signaling molecules that control different developmental arrests

This paper identifies a multifunctional PKS-NRPS hybrid in nematodes that produces diverse signaling molecules controlling different developmental arrests.

Plasticity in nonsense-mediated decay and translation initiation regulate polyphenism

The paper investigates natural variation in mouth-form plasticity in Pristionchus pacificus, linking it to genetic and molecular mechanisms involving nonsense-mediated decay and alternative start codon selection.

A unique Cysteine-type protein domain regulates cuticular extracellular matrix assembly in nematodes

The paper identifies a unique cysteine motif in DPY-6 that facilitates dimerization and is involved in cuticle formation in nematodes.

Poly(UG)-tailed RNAs are involved in the control of thousands of genes predominantly in the germline in Pristionchus pacificus

The paper shows poly(UG)-tailed RNAs induce gene knockdown in Pristionchus pacificus and are abundant in germline-specific genes, with mutations affecting fertility.

Biosynthesis of modular signaling molecules requires functional diversification of carboxylesterases in Pristionchus pacificus

This study identifies three new carboxylesterases in Pristionchus pacificus that function in the biosynthesis of specific modular pheromones, revealing their substrate-specific roles in pheromone complexity.

Functional divergence of conserved developmental plasticity genes between two distantly related nematodes

This study examines functional divergence of developmental plasticity genes between two nematode species using CRISPR mutations, revealing conservation, new functions, and quantitative effects in mouth-form regulation.

Diet-derived vitamin B12 induces transgenerational inheritance of nematode predation through elevated vitellogenin provisioning

This study shows that vitamin B12 from diet induces transgenerational inheritance of predatory behavior in nematodes through increased vitellogenin provisioning.

EBAX-1/ZSWIM8 destabilizes miRNAs resulting in transgenerational memory of a predatory trait

The paper shows that EBAX-1/ZSWIM8 destabilizes miRNAs, leading to transgenerational memory of a predatory trait in nematodes.

High nutritional conditions influence feeding plasticity in Pristionchus pacificus and render worms non-predatory

This study shows that high nutritional conditions, particularly glucose, induce non-predatory mouth-form polyphenism in Pristionchus pacificus through fatty acid synthesis and beta-oxidation pathways.

Developmental small RNA transcriptomics reveals divergent evolution of the conserved microRNA miR-100 and the let-7-complex in nematodes

The paper performs small RNA sequencing in Pristionchus pacificus to study miR-100 and the let-7-complex, finding novel miRNAs, developmental expression patterns, and alternative locus arrangements.

Influence of environmental temperature on mouth-form plasticity in Pristionchus pacificus acts through daf-11-dependent cGMP signaling

This study shows that temperature influences mouth-form plasticity in Pristionchus pacificus through daf-11-dependent cGMP signaling involving DAF-11, DAF-25, and TAX-2.

Comparative genomics and community curation further improve gene annotations in the nematode Pristionchus pacificus

The paper improves gene annotations in Pristionchus pacificus by combining comparative genomics and community curation, resulting in a higher quality gene set with improved ortholog completeness.

Conserved nuclear receptors controlling a novel trait target fast-evolving genes expressed in a single cell

The paper identifies conserved nuclear receptors that regulate fast-evolving genes involved in morphological changes in nematodes.