Michael S. Werner

The paper shows WDR5 binds RNA non-specifically, displacing it from the MLL1 complex and inhibiting its catalytic activity.

The paper identifies two environmentally sensitive genes in a plasticity gene regulatory network and reveals metabolism as a shared pathway for mouth-form plasticity in Pristionchus.

The paper performs small RNA sequencing in Pristionchus pacificus to study miR-100 and the let-7-complex, finding novel miRNAs, developmental expression patterns, and alternative locus arrangements.

The paper identifies the epigenetic toolkit of Pristionchus pacificus, revealing the loss of the PRC2 complex and the presence of H3K27me3 through an unknown methyltransferase.

The paper shows that histone 4 lysine 5/12 acetylation regulates developmental plasticity and epigenetic memory in nematodes by controlling switch gene expression during a critical environmental sensitivity window.

This study identifies WDR76 as a hmC-specific protein that promotes MLL-rearranged leukemia by modulating gene expression and facilitating leukemogenesis.

The paper shows that adult-specific pheromones induce predatory morph in juvenile nematodes, revealing age-dependent cross-generational signaling in phenotypic plasticity.