Tomas Marques-Bonet

An evolutionary medicine perspective on Neandertal extinction

This study compares genetic diversity in immune-related genes between Neandertals and modern humans, finding lower diversity in Neandertals which may have made them more susceptible to pathogens.

The interplay between DNA methylation and sequence divergence in recent human evolution

This study identifies human-specific DNA methylation patterns and their relationship with genetic variation in humans and great apes.

Tandem repeat variation in human and great ape populations and its impact on gene expression divergence

This study analyzes tandem repeat variation across human and great ape genomes and its effect on gene expression divergence.

An Approximate Bayesian Computation Approach to Examining the Phylogenetic Relationships among the Four Gibbon Genera using Whole Genome Sequence Data

This study uses whole genome sequencing and Approximate Bayesian Computation to examine gibbon phylogenetic relationships, finding that all four genera diverged around 5 Mya with unresolved branching order.

Generation of a Panel of Induced Pluripotent Stem Cells From Chimpanzees: a Resource for Comparative Functional Genomics

The paper generates a panel of chimpanzee iPSCs and compares their regulatory variation with somatic cells and human iPSCs, finding reduced species-specific differences in iPSCs.