Bryan J. Pavlovic

The paper identifies human-specific gene regulation in telencephalic progenitors by analyzing morphogen-dependent gene expression responses across human, chimpanzee, and orangutan species.

CellBouncer demultiplexes and analyzes pooled single-cell data, revealing mitochondrial incompatibilities between humans and chimpanzees.

The paper identifies transcription factors and effector genes involved in human cortical neurogenesis using CRISPRi screening in a primary culture system.

The paper identifies a segmental duplication that drives position effect expression of TBC1D3 in the human brain, explaining its high structural heterozygosity.

The paper identifies human-specific deletions that affect gene expression by using CRISPRi screening in chimpanzee stem cells.

The paper identifies HAQERs in human cortical development, showing their role in gene regulation through CpG gains and links them to neurological disorders.

ANTIPODE integrates single-cell data across species to identify homologous cell types and reveal gene regulatory divergence in developing mammalian brains.

This study compares gene expression variability and eQTLs in humans and chimpanzees, finding shared genetic and non-genetic determinants of inter-individual expression differences.

The paper uses chimpanzee cerebral organoids to identify human-specific genes in cortical development and finds increased PI3K/AKT/mTOR activation in human outer radial glia.

This study compares endoderm differentiation in humans and chimpanzees using iPSCs, finding high conservation of gene regulatory trajectories despite species-specific expression differences.

The paper compares gene expression and regulatory differences between human and chimpanzee iPSC-derived cardiomyocytes and primary heart tissues to assess their utility for comparative genomic studies.

The paper examines H3K9me3 marking of transposable elements in human and chimpanzee induced pluripotent stem cells, finding limited species-specificity and no strong link to gene expression divergence.

The paper examines regulatory variation in iPSCs and differentiated cells, finding lower individual variation in iPSCs and identifying shared chromatin regions for some cell type-specific QTLs.

The paper generates a panel of chimpanzee iPSCs and compares their regulatory variation with somatic cells and human iPSCs, finding reduced species-specific differences in iPSCs.