Jonathan E. Burnett

Genetic Determinants of Cell-Type-Specific Responses to Cardiotoxic Chemotherapeutic Agents

The paper identifies genetic variants associated with cardiotoxic responses to chemotherapeutic drugs using single-cell RNA-seq and eQTL analysis.

Disease-associated loci share properties with response eQTLs under common environmental exposures

The paper identifies response eQTLs associated with environmental exposures in human cells and finds they overlap with disease-associated loci not explained by steady-state eQTLs.

Characterizing and inferring quantitative cell cycle phase in single-cell RNA-seq data analysis

The paper develops a method to quantify cell cycle progression in scRNA-seq data using a small number of genes, showing it can predict cell cycle phase within 14% accuracy.

Systematic Comparison of High-throughput Single-Cell and Single-Nucleus Transcriptomes during Cardiomyocyte Differentiation

The paper compares Drop-seq and DroNc-seq in profiling cardiomyocyte differentiation, finding similar cell types and trajectories in both methods.

Discovery and characterization of variance QTLs in human induced pluripotent stem cells

This study identifies variance QTLs (vQTLs) in human iPSCs using scRNA-seq, finding that genetic variants affect gene expression variance but with smaller phenotypic impact than mean expression QTLs.

Impact of regulatory variation across human iPSCs and differentiated cells

The paper examines regulatory variation in iPSCs and differentiated cells, finding lower individual variation in iPSCs and identifying shared chromatin regions for some cell type-specific QTLs.

Generation of a Panel of Induced Pluripotent Stem Cells From Chimpanzees: a Resource for Comparative Functional Genomics

The paper generates a panel of chimpanzee iPSCs and compares their regulatory variation with somatic cells and human iPSCs, finding reduced species-specific differences in iPSCs.