A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24
Perpetual Nyame, Akihiro Togami, Tomofumi Yoshida, Takuya Masunaga, MST Monira Begum, Hiromi Terasawa, Nami Monde, Yurika Tahara, Reiko J. Tanaka, Yuetsu Tanaka, Joyce Appiah-Kubi, Wright Andrews Ofotsu Amesimeku, Md Jakir Hossain, Masami Otsuka, Kazuhisa Yoshimura, , Kazuaki Monde
This paper identifies a heterocyclic compound, HT-7, that inhibits HIV-1 release by increasing cell surface BST2 expression with minimal cellular toxicity.
Journal of Biological Chemistry · Aug 22, 2024Peer-reviewedMicrobiology