Kazuaki Monde

HIV-1 can undergo Env-independent retrotransposon-like activity

This study shows HIV-1 can perform reverse transcription and partial integration without Env or infection, suggesting a retrotransposon-like mechanism.

APOBEC3 antagonism fully explains HIV-1 Vif essentiality under interferon and differentiation conditions

This study shows that HIV-1 Vif's essential role in infectivity under interferon and differentiation conditions is fully explained by its antagonism of APOBEC3 proteins, not other targets.

M-Sec promotes the production of infectious HIV-1 virus through the exocyst complex

This paper shows that M-Sec promotes HIV-1 production by facilitating Gag puncta formation and Env incorporation through PIP2, Ral, and the exocyst complex.

Lenacapavir binding to immature Gag triggers the emergence of giant HIV-1 virions

The paper shows lenacapavir binding to immature Gag leads to non-infectious giant HIV-1 virions with altered structure and function.

Identification of M-Sec as a unique cellular regulator of CSF-1 receptor activation

This study identifies M-Sec as a regulator of CSF-1 receptor activation by promoting Fms aggregate formation through PIP2 binding.

A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24

This paper identifies a heterocyclic compound, HT-7, that inhibits HIV-1 release by increasing cell surface BST2 expression with minimal cellular toxicity.