Masami Otsuka

This study reports the structure of the dimeric Keap1 Kelch domain at ambient temperature and identifies a novel compound, CNN, as a potential lead for Keap1 inhibition.

This paper identifies a heterocyclic compound, HT-7, that inhibits HIV-1 release by increasing cell surface BST2 expression with minimal cellular toxicity.

The paper presents the structure of TRAF6 N-terminal domain at 2.6 Å resolution, providing insights into its domain organization and zinc-binding, which are critical for its function and therapeutic targeting.