IGF2BP3 is essential for the growth heterogeneity of colorectal adenoma cells by regulating MYC
Tomohiko Sunami, Roberto Coppo, Kunishige Onuma, Jumpei Kondo, Hiroyuki Uematsu, Daisuke Hoshi, Yoshihiro Yamamoto, Osamu Kikuchi, Shinya Ohashi, Yasuhide Takeuchi, Kazuto Kugou, Yoshinori Hasegawa, Yoshiro Itatani, Kazutaka Obama, Yoshitaka Hippo, , Masahiro Inoue
The paper identifies IGF2BP3 as a regulator of MYC that contributes to growth heterogeneity in colorectal adenoma cells through both transcriptional and translational mechanisms.
iScience · Jun 26, 2026Peer-reviewedCancer Biology