CART-GPT: A T Cell-Informed AI Linguistic Framework for Interpreting Neurotoxicity and Therapeutic Outcomes in CAR-T Therapy
Tiantian Mao, Xiaojian Shao, Wei Guo, Zhiwu Jiang, Rui Jing, Xin Li, Yiran Zhu, Tony Jin, Tao Ma, Yong Lu, Guangxu Jin
CART-GPT predicts CAR-T therapy efficacy and neurotoxicity risk using a transformer model trained on 1.12 million single-cell RNA-seq profiles with clinical outcomes.
bioRxiv · Aug 8, 2025 · PreprintBioinformatics