Transgenic mice overexpressing Pitx2 in the atria develop tachycardia-bradycardia syndrome
Shunsuke Baba, Satoko Shinjo, Daiki Seya, Hiroki Bochimoto, Toru Akaike, Atsushi Nakano, Susumu Minamisawa
This study shows that overexpression of Pitx2c in the atria of mice leads to SAN dysfunction and TBS-like pathology, including prolonged SAN recovery time and increased AF inducibility.
PLoS ONE · Sep 4, 2025Peer-reviewedDevelopmental Biology