Developmental BiologyPLoS ONEPeer-reviewed
Transgenic mice overexpressing Pitx2 in the atria develop tachycardia-bradycardia syndrome
Shunsuke Baba, Satoko Shinjo, Daiki Seya…·Susumu Minamisawa
This study shows that overexpression of Pitx2c in the atria of mice leads to SAN dysfunction and TBS-like pathology, including prolonged SAN recovery time and increased AF inducibility.
DOI 10.1371/journal.pone.0330397