Cell BiologybioRxivPreprint
Endothelial RRM2B-dependent mitochondrial DNA signalling drives doxorubicin-cardiotoxicity
SILVIA GRAZIANI, Altea Bonello, Raquel Brañas Casas…·Giovanna Pontarin
This study identifies endothelial RRM2B-dependent mitochondrial DNA signaling as a driver of doxorubicin-induced cardiotoxicity and shows that Eltrombopag can prevent it.