Daiki Seya

The paper maps lineage trajectories and gene regulatory networks of cardiopharyngeal neural crest cells in mice, identifying a Hox-Meis-regulated transition associated with cardiac cushion development.

This study shows that overexpression of Pitx2c in the atria of mice leads to SAN dysfunction and TBS-like pathology, including prolonged SAN recovery time and increased AF inducibility.

The paper uses multimodal analysis to reveal cardiac neural crest lineage diversity and gene regulatory networks involved in their differentiation.