Interleukin-13-mediated alterations in esophageal epithelial mitochondria contribute to tissue remodeling in eosinophilic esophagitis
Jazmyne L. Jackson, Reshu Saxena, Mary Grace Murray, Anne Staub, Alena Klochkova, Travis H. Bordner, Courtney Worrell, Annie D. Fuller, John M. Crespo, Andres J. Klein–Szanto, John W. Elrod, Tatiana A. Karakasheva, Melanie A. Ruffner, Amanda B. Muir, Kelly A. Whelan
This study identifies IL-13 as a driver of increased mitochondrial mass in esophageal keratinocytes, impairing squamous cell differentiation and contributing to eosinophilic esophagitis.
bioRxiv · Apr 2, 2025 · PreprintMolecular Biology