Tatiana A. Karakasheva

The paper uses scRNA-seq to compare IL-13-treated esophageal organoids with EoE biopsies, revealing shared cell state heterogeneity and differentiation hierarchy dysregulation.

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

This study shows that Prostaglandin E2 reverses myofibroblast differentiation in EoE via the cAMP/YAP/THBS-1 pathway, suggesting it as a potential treatment for fibrostenotic EoE.

The paper identifies an inflammatory secretory progenitor cell state in Crohn's disease patients and shows its epigenetic regulation in stem cells.

This study finds BRCA1 and BRCA2 carriers have increased DNA damage and growth in gastric epithelium and organoids, suggesting haploinsufficiency contributes to early gastric cancer development.

This study identifies FOXM1 as a key driver of epithelial disruption in EoE, showing that its inhibition restores differentiation, reduces hyperplasia, and improves barrier function.

This study identifies IL-13 as a driver of increased mitochondrial mass in esophageal keratinocytes, impairing squamous cell differentiation and contributing to eosinophilic esophagitis.

This study investigates the role of TNFSF13 in colonic epithelial cell-B cell interactions and finds that TNFSF13 insufficiency disrupts B cell differentiation and epithelial growth.

The paper identifies clonal cell states in Barrett's esophagus and links them to esophageal adenocarcinoma progression through single-cell lineage tracing and transcriptional profiling.

This study uses single-cell RNA sequencing to identify cellular diversity and age-related mitochondrial dysfunction in murine esophageal epithelium.