Melanie A. Ruffner

Systemic Analysis of Patient Derived Esophageal Epithelial Organoid Model Reveals Cell State Heterogeneity and Conservation of Differentiation Hierarchy

The paper uses scRNA-seq to compare IL-13-treated esophageal organoids with EoE biopsies, revealing shared cell state heterogeneity and differentiation hierarchy dysregulation.

NIX-associated mitochondrial remodeling contributes to esophageal epithelial differentiation

This study shows that NIX-mediated mitochondrial remodeling is essential for esophageal epithelial differentiation and that its disruption may contribute to eosinophilic esophagitis.

T cell dysregulation and remodeling in pediatric obesity and weight loss

This study identifies T cell dysregulation in pediatric obesity and shows that these changes persist despite weight loss.

Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils

This study shows that omeprazole modulates esophageal epithelial barrier function and reduces eosinophil activation in an IL-13-induced model of eosinophilic esophagitis.

FOXM1 Modulation Alleviates Epithelial Remodeling and Inflammation in Eosinophilic Esophagitis

This study identifies FOXM1 as a key driver of epithelial disruption in EoE, showing that its inhibition restores differentiation, reduces hyperplasia, and improves barrier function.

Interleukin-13-mediated alterations in esophageal epithelial mitochondria contribute to tissue remodeling in eosinophilic esophagitis

This study identifies IL-13 as a driver of increased mitochondrial mass in esophageal keratinocytes, impairing squamous cell differentiation and contributing to eosinophilic esophagitis.