Hierarchical control of remyelination by heparan sulfate sulfation
Rupadevi Muthaiah, Roopa Ravichandar, Rathnakar Poddeti, Aneri P Shah, Bhargavi Kulkarni, Trina Rudra, Ding Xu, Nagendra Rai, Ranjan Dutta, Fraser J. Sim
This study identifies hierarchical control of remyelination by heparan sulfate sulfation patterns, showing that 2-O sulfation suppresses BMP and WNT signaling to promote remyelination.
bioRxiv · Sep 29, 2026 · PreprintNeuroscience