Fraser J. Sim

This study identifies hierarchical control of remyelination by heparan sulfate sulfation patterns, showing that 2-O sulfation suppresses BMP and WNT signaling to promote remyelination.

This study identifies striatin-3 as a Rac1 interactor and shows its role in Schwann cell radial sorting and Hippo pathway regulation during peripheral nervous system development.

This study uses iPSC-derived myelinating organoids and microglia from Krabbe Disease patients to investigate early myelination defects and globoid cell formation mechanisms.

This study shows that p38γMAPK inhibits oligodendrocyte differentiation and myelin repair, and is enriched in multiple sclerosis lesions.

This study shows that chronic demyelination in rabbit CNS is associated with reduced oligodendrocyte progenitor cell (OPC) repopulation, regardless of lesion size, and highlights species-specific differences in remyelination mechanisms.

This study shows that Gq-coupled receptor activation induces oscillatory calcium signaling in hOPCs, which blocks differentiation and promotes proliferation through SOCE, suggesting potential therapeutic targets for myelin repair.

This study identifies Sulf1/2 as a key inhibitor of oligodendrocyte progenitor cell recruitment and remyelination in chronic demyelination, showing that sulfatase inhibition can enhance remyelination.