Ding Xu

This study identifies hierarchical control of remyelination by heparan sulfate sulfation patterns, showing that 2-O sulfation suppresses BMP and WNT signaling to promote remyelination.

This study identifies an RBP-J-HS-dependent network that regulates macrophage fate between inflammation and osteoclastogenesis in response to TNF.

This study shows heparan sulfate inhibits MMP13 collagenase activity but not non-collagen substrate degradation, revealing HS as a regulator of MMP13 through exosite binding.

This study shows heparan sulfate promotes pro-CtsK autoprocessing by disrupting an electrostatic interaction between the propeptide and catalytic domain.

This study shows heparan sulfate inhibits cathepsin K collagenase activity while preserving peptidase activity, revealing HS as a potential therapeutic target for bone resorption diseases.