Ranjan Dutta

This study identifies hierarchical control of remyelination by heparan sulfate sulfation patterns, showing that 2-O sulfation suppresses BMP and WNT signaling to promote remyelination.

This study identifies lesion-remote astrocytes (LRAs) that drive microglia-mediated white matter repair after spinal cord injury through Ccn1-dependent mechanisms.

The paper analyzes extracellular vesicles from MS and control white matter to identify pathway dysregulation and cellular origin shifts associated with the disease.

This study integrates multi-omics data using network medicine to identify potential drug targets and repurposable treatments for ALS.

This study shows that p38γMAPK inhibits oligodendrocyte differentiation and myelin repair, and is enriched in multiple sclerosis lesions.

This study shows that Dicer deficiency in microglia accelerates demyelination and impairs remyelination by affecting oligodendrocyte progenitor cells and microglial function.

This study shows astrocytic IFN-gamma signaling reduces inflammation in MS via PD-L1, suggesting therapeutic potential.

The paper uses snRNA-seq to compare cell type-specific transcriptomic changes between RRMS and SPMS in non-lesioned brain regions, identifying downregulation of astrocytic sphingosine kinases in SPMS.

This study identifies Sulf1/2 as a key inhibitor of oligodendrocyte progenitor cell recruitment and remyelination in chronic demyelination, showing that sulfatase inhibition can enhance remyelination.

This study shows bile acid metabolism is altered in multiple sclerosis, and supplementation with tauroursodeoxycholic acid reduces neuroinflammation in animal models.

This study shows OPCs can cross-present antigen and mediate cytotoxicity in MS, suggesting they are co-opted by the immune system.