Adenylate kinase-4 modulates oxidative stress and stabilizes HIF-1α to drive lung cancer metastasis
Yi-Hua Jan, Tsung-Ching Lai, Chih-Jen Yang, Yuan-Feng Lin, Ming-Shyan Huang, Michael Hsiao
This study identifies AK4 as a driver of lung cancer metastasis by modulating oxidative stress and stabilizing HIF-1α, with potential therapeutic targeting of the AK4-HIF-1 axis.
bioRxiv · Oct 1, 2017 · PreprintCancer Biology