Author

Chih-Jen Yang

Kaohsiung Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Assay:GWAS summary statistics· 1 Research Focus:polygenic risk· 1 Approach:statistical model· 1

Frequent Co-Authors

An‐Chieh FengiD· 1 shared Bi-Zhen Kao· 1 shared Che-Yu ChouiD· 1 shared Cheng-Shin YangiD· 1 shared Chi-Lu Chiang· 1 shared Chi‐Li ChungiD· 1 shared Chia-Hsin Chen· 1 shared Chieh-Hua Lu· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

An‐Chieh FengORCID

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2 papers

Recent·Most cited

Population-Specific Polygenic Risk Scores Developed for the Han Chinese

Hung‐Hsin Chen, Chien-Hsiun Chen, Ming‐Chih Hou, Yun‐Ching Fu, Ling‐Hui Li, Che-Yu Chou, Erh‐Chan Yeh, Ming-Fang Tsai, Chun-houh Chen, Hsin‐Chou Yang, Yen‐Tsung Huang, Yi-Min Liu, Chun-Yu Wei, Jen-Ping Su, Wan-Jia Lin, , Chih‐Yang Huang

The paper develops population-specific polygenic risk scores for Han Chinese using genomic and electronic health record data, showing strong predictive performance for multiple diseases.

Nature · Oct 15, 2025Peer-reviewedGenetic & Genomic Medicine

Adenylate kinase-4 modulates oxidative stress and stabilizes HIF-1α to drive lung cancer metastasis

Yi-Hua Jan, Tsung-Ching Lai, Chih-Jen Yang, Yuan-Feng Lin, Ming-Shyan Huang, Michael Hsiao

This study identifies AK4 as a driver of lung cancer metastasis by modulating oxidative stress and stabilizing HIF-1α, with potential therapeutic targeting of the AK4-HIF-1 axis.

bioRxiv · Oct 1, 2017 · PreprintCancer Biology