E-box independent chromatin recruitment turns MYOD into a transcriptional repressor
Chiara Nicoletti, Jimmy Massenet, Andreas P. Pintado-Urbanc, Leah J. Connor, Monica M Nicolau, Swetha Sundar, Mingzhi Xu, Anthony D. Schmitt, Wenxin Zhang, Zesen Fang, Tsz Ching Chan, Stephen J. Tapscott, Tom H. Cheung, Matthew D. Simon, Luca Caputo, Prem Puri
This paper identifies a new function of MYOD as a transcriptional repressor through E-box-independent chromatin binding, revealing a mechanism to repress gene expression and maintain cell identity during myogenesis.
bioRxiv · Dec 5, 2024 · PreprintMolecular Biology