Author

Monica M Nicolau

Sanford Burnham Prebys Medical Discovery InstituteORCID 0009-0004-6534-1874Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Luca CaputoiD· 4 shared Prem PuriiD· 4 shared Jesus R BarajasiD· 3 shared Chiara NicolettiiD· 2 shared Jimmy MassenetiD· 2 shared Maira RossiiD· 2 shared Tom H. CheungiD· 2 shared Alessandra CecchiniiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersMolecular Biology

Luca CaputoORCID

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4 papers

Recent·Most cited

Ctcf deficiency in myofibers induces pathological genome reprogramming toward the spontaneous development of myopathy

Jimmy Massenet, Chiara Nicoletti, Luca Caputo, Sören S. Hüttner, Monica M Nicolau, Jesus R Barajas, Maira Rossi, Yuqing Yang, Yu Xin Wang, Tom H. Cheung, Michael Witcher, Colin G. Crist, Prem Puri

This study shows that Ctcf deficiency in myofibers leads to genome reprogramming and myopathy by disrupting 3D genome structure and gene regulation.

bioRxiv · Oct 14, 2026 · PreprintMolecular Biology

Novel role of the lncRNA EPR as oncosuppressor in intestinal cancer.

Naomi Shim, Maira Rossi, Monica M Nicolau, Jesus R Barajas, Ettore Zapparoli, Paola Briata, Prem Puri, Roberto Gherzi, Luca Caputo

The paper identifies EPR as an oncosuppressor in intestinal cancer, showing its role in goblet cell development and its potential as a prognostic marker and therapeutic target.

bioRxiv · May 1, 2026 · PreprintCancer Biology

Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSCs-derived myogenic progenitor cells

Luca Caputo, Cedomir Stamenkovic, Matthew Timothy Tierney, Alessandra Cecchini, Monica M Nicolau, Gabriele Guarnaccia, Jesus R Barajas, Maria Sofia Falzarano, Rhonda Bassel‐Duby, Alessandra Ferlini, Eric N. Olson, Prem Puri, Alessandra Sacco

The paper shows that modulating the JAK2-STAT3 pathway enhances the yield and maturation of human iPSC-derived myogenic progenitor cells for potential cell therapy.

Stem Cell Reports · Oct 30, 2025Peer-reviewedCell Biology

E-box independent chromatin recruitment turns MYOD into a transcriptional repressor

Chiara Nicoletti, Jimmy Massenet, Andreas P. Pintado-Urbanc, Leah J. Connor, Monica M Nicolau, Swetha Sundar, Mingzhi Xu, Anthony D. Schmitt, Wenxin Zhang, Zesen Fang, Tsz Ching Chan, Stephen J. Tapscott, Tom H. Cheung, Matthew D. Simon, Luca Caputo, Prem Puri

This paper identifies a new function of MYOD as a transcriptional repressor through E-box-independent chromatin binding, revealing a mechanism to repress gene expression and maintain cell identity during myogenesis.

bioRxiv · Dec 5, 2024 · PreprintMolecular Biology