Andreas P. Pintado-Urbanc

HaloPROTAC-mediated degradation reveals SOX10-dependent gene expression changes in melanoma cells

This study uses HaloPROTAC-mediated SOX10 degradation in melanoma cells to identify novel target genes and reveal SOX10's role in drug resistance and metastasis.

Histone H4 acetyl-methyllysine marks accessible chromatin that resists compaction

The paper identifies Kacme as a histone modification marking accessible chromatin that resists compaction, particularly at regulatory regions and insulator elements.

RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and WNT pathway activation

This study shows that the RBM15-MKL1 fusion protein drives leukemia through m6A methylation and WNT pathway activation, with METTL3 inhibition reducing tumor growth.

E-box independent chromatin recruitment turns MYOD into a transcriptional repressor

This paper identifies a new function of MYOD as a transcriptional repressor through E-box-independent chromatin binding, revealing a mechanism to repress gene expression and maintain cell identity during myogenesis.

Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination

This study identifies ELOF1 as a critical factor for somatic hypermutation and class switch recombination by facilitating RNAPII pausing and AID targeting.