Inhibition of Glutamine Metabolism Suppresses Tumor Progression through Remodeling of the Macrophage Immune Microenvironment
Tianhe Li, Sepehr Akhtarkhavari, Tu-Yung Chang, Yao Shen, Jinming Yang, Barbara Stauch Slusher, Ie‐Ming Shih, Stephanie L. Gaillard, Tian‐Li Wang
This study shows that inhibiting glutamine metabolism with JHU083 reduces tumor progression by altering macrophage polarization in immunocompetent mouse models.
bioRxiv · Jan 10, 2025 · PreprintCancer Biology