Ie‐Ming Shih

Cross-species analysis links cell-cell communication rewiring to NOTCH2 during serous endometrial carcinogenesis

Targeting Tumor Immunity: Statins as a Repurposed Strategy for Preventing Ovarian Cancer Advancement

This study investigates the effect of statins on ovarian cancer survival, finding that atorvastatin improves survival and enhances immune activation in preclinical models.

3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors

The paper presents a 3D multi-omic framework to detect and characterize ovarian cancer precursors in fallopian tubes, identifying TP53 mutations in microscopic lesions.

Modulating Glutamine Metabolism Reprograms Pro-Inflammatory Differentiation in Macrophages

This study shows that glutamine inhibition affects M1 macrophage polarization differently over time, enhancing pro-inflammatory activity while suppressing immunosuppressive macrophages.

Integrated Spatial Analysis of Ovarian Precancerous Lesions

The paper identifies four subtypes of ovarian precancerous lesions and links them to genetic and molecular features associated with cancer progression.

Inhibition of Glutamine Metabolism Suppresses Tumor Progression through Remodeling of the Macrophage Immune Microenvironment

This study shows that inhibiting glutamine metabolism with JHU083 reduces tumor progression by altering macrophage polarization in immunocompetent mouse models.

Gene model correction for PVRIG in single cell and bulk sequencing data enables accurate detection and study of its functional relevance

The paper corrects gene models for PVRIG in scRNA-seq and bulk data, improving its detection and enabling accurate functional analysis.