Unraveling the Molecular Landscape of Uterine Fibroids, Insights into HMGA2 and Stem Cell Involvement
Emmanuel N. Paul, Tyler J. Carpenter, Laura A. Pavliscak, Abigail Z. Bennett, Maria Ariadna Ochoa-Bernal, Asgerally T. Fazleabas, Jose M. Teixeira
This study investigates HMGA2 overexpression in myometrial cells, showing it induces a stem cell-like state and contributes to fibroid development through dedifferentiation and altered extracellular matrix pathways.
bioRxiv · Apr 26, 2024 · PreprintMolecular Biology