Author

Tyler O'Hara

Children's Hospital of Philadelphia

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Cell Biology· 1

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Organism:C. elegans· 1 Approach:experimental assay· 1

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Cristina RemeşiD· 1 shared Eiko Nakamaru‐OgisoiD· 1 shared Kelsey KeithiD· 1 shared Manuela LavoratoiD· 1 shared Marni J. FalkiD· 1 shared Neal D. MathewiD· 1 shared Rui XiaoiD· 1 shared Suraiya HarooniD· 1 shared

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1 shared paperCell Biology

Cristina RemeşORCID

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1 paper

Recent·Most cited

Cell BiologyJournal of Inherited Metabolic DiseasePeer-reviewedOct 7, 2026

Dichloroacetate improves animal survival, growth, neuromuscular activity, mitochondrial stress and physiology, and elevated lactate in C. elegans pdha-1 and dld-1 RNAi models of pyruvate dehydrogenase complex deficiency (PDCD)

Cristina Remeş, Neal D. Mathew, Victoria Miranda…·Marni J. Falk

This paper shows that DCA improves survival, growth, neuromuscular activity, mitochondrial function, and reduces lactate in C. elegans models of PDHc deficiency.

DOI 10.1002/jimd.70257

C. elegansexperimental assay

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