Neal D. Mathew

This paper shows that DCA improves survival, growth, neuromuscular activity, mitochondrial function, and reduces lactate in C. elegans models of PDHc deficiency.

This study shows that cognate amino acid treatment improves growth, neuromuscular function, and reduces stress in 19 C. elegans models of mt-ARS deficiency.

This study identifies UBR-1 as a hub regulating glutamate homeostasis through a signaling axis, affecting locomotion and developmental viability in C. elegans.

This study generates ndufs2-/- zebrafish with CI deficiency, showing metabolic and neuromuscular defects treatable by folic acid.

This study shows that N-glycosylation of MRS2, a mitochondrial Mg2+ transporter, regulates Mg2+ influx and balances energy production under high glucose or impaired respiration.

The paper introduces FusXTBE, a TALE base editor for editing mtDNA in human cells and zebrafish, achieving high editing efficiency and precision.