Suraiya Haroon

Dichloroacetate improves animal survival, growth, neuromuscular activity, mitochondrial stress and physiology, and elevated lactate in C. elegans pdha-1 and dld-1 RNAi models of pyruvate dehydrogenase complex deficiency (PDCD)

This paper shows that DCA improves survival, growth, neuromuscular activity, mitochondrial function, and reduces lactate in C. elegans models of PDHc deficiency.

KIN-29 SIK regulates stress-induced sleep through mitochondrial redox signaling

This study shows that KIN-29 regulates stress-induced sleep in C. elegans via mitochondrial ROS signaling, with ROS acting downstream of KIN-29 and upstream of the ALA neuron.

Targeted modulation of IGFBP5/IGF1, THPO, and P38 MAPK signaling are potent therapeutic strategies generalizable for mitochondrial respiratory chain disease and osteosarcoma

The paper identifies THPO, IGF1, and MAPK as therapeutic targets for mitochondrial respiratory chain disease and osteosarcoma, showing their modulation can replicate the benefits of CHX treatment.

Targeting the Mitochondrial Phenotype in Cockayne Syndrome Patient Cells: From Bioenergetic Fragility to Pharmacologic Rescue

This study identifies five compounds that improve mitochondrial function and survival in Cockayne syndrome patient fibroblasts by targeting oxidative stress, autophagy, and cellular resilience.

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome

This study shows that reduced IGF-1 signaling extends lifespan in mammals but not in mitochondrial mutator mice, indicating that mitochondrial genome stability is essential for the longevity benefits of IGF-1 suppression.

Mitophagy modulation rescues single large-scale mitochondrial DNA deletion (SLSMD) disease symptoms in the C. elegans uaDf5 animal model.

This study identifies therapeutic candidates for SLSMD diseases by screening mitophagy modulators in a C. elegans model, showing that Celastrol reduces mitochondrial stress and improves health outcomes.