Distinct SARS-CoV-2 sensing pathways in pDCs driving TLR7-antiviral vs. TLR2-immunopathological responses in COVID-19
R. M. van der Sluis, L. B. Cham, A. G. Oliver, K. R. Gammelgaard, J. G. Pedersen, M. Idorn, U. Ahmodov, S. S. Hernandez, E. Cemalovic, S. H. Godsk, J. Thyrsted, J. D. Gunst, S. D. Nielsen, J. j. Jorgensen, T. W. Bjerg, , M. R. Jakobsen
The paper shows that pDCs use TLR7 for antiviral responses and TLR2 for inflammatory responses to SARS-CoV-2, with neuropilin-1 inhibiting antiviral IFNs.
bioRxiv · Nov 23, 2021 · PreprintImmunology