Author

M. Idorn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

S. R. Paludan· 4 shared C. K. Holm· 3 shared D. Olagnier· 3 shared E. B. Svenningsen· 2 shared J. Rehwinkel· 2 shared J. Thyrsted· 2 shared L. Reinert· 2 shared T. B. Poulsen· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersImmunology

S. R. Paludan

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Distinct SARS-CoV-2 sensing pathways in pDCs driving TLR7-antiviral vs. TLR2-immunopathological responses in COVID-19

R. M. van der Sluis, L. B. Cham, A. G. Oliver, K. R. Gammelgaard, J. G. Pedersen, M. Idorn, U. Ahmodov, S. S. Hernandez, E. Cemalovic, S. H. Godsk, J. Thyrsted, J. D. Gunst, S. D. Nielsen, J. j. Jorgensen, T. W. Bjerg, , M. R. Jakobsen

The paper shows that pDCs use TLR7 for antiviral responses and TLR2 for inflammatory responses to SARS-CoV-2, with neuropilin-1 inhibiting antiviral IFNs.

bioRxiv · Nov 23, 2021 · PreprintImmunology

ZBP1 induces inflammatory signaling via RIPK3 and promotes SARS-CoV-2-induced cytokine expression

R. Peng, X. Wang-Kan, M. Idorn, F. Y. Zhou, S. L. Orozco, J. McCarthy, C. S. Leung, X. Lu, K. Bagola, J. Rehwinkel, A. Oberst, J. Maelfait, S. R. Paludan, M. Gyrd-Hansen

This study identifies a ZBP1-RIPK1-RIPK3 pathway that promotes SARS-CoV-2-induced cytokine expression through inflammatory signaling independent of cell death.

bioRxiv · Oct 1, 2021 · PreprintImmunology

Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

D. Olagnier, E. Farahani, J. Thyrsted, J. B. Cadanet, A. Herengt, M. Idorn, A. Hait, B. Hernaez, A. Knudsen, M. B. Iversen, M. Schilling, S. E. Jorgensen, M. Thomsen, L. Reinert, M. Lappe, , C. K. Holm

The paper identifies NRF2 agonists 4-OI and DMF as inhibitors of SARS-CoV2 replication and inflammatory responses, effective against multiple viruses.

bioRxiv · Jul 16, 2020Microbiology

Ionophore antibiotic X-206 is a potent and selective inhibitor of SARS-CoV-2 infection in vitro

E. B. Svenningsen, J. T. Jensen, J. Blay-Cadanet, H. Liu, S. Lin, J. M. Villameriel, D. Olagnier, M. Idorn, S. R. Paludan, C. K. Holm, T. B. Poulsen

This study identifies X-206, a polyether ionophore antibiotic, as a potent and selective inhibitor of SARS-CoV-2 infection in vitro with high selectivity and sub-nM efficacy.

bioRxiv · Jun 14, 2020Pharmacology & Toxicology