Author

U. Jayachandran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. G. Cook· 2 shared A. Kasprowicz· 1 shared A. Machado de Amorim· 1 shared A. P. Bird· 1 shared B. Alexander-Howden· 1 shared D. Tollervey· 1 shared E. W. J. Wallace· 1 shared G. Xue· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

A. G. Cook

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Author profile →

3 papers

Recent·Most cited

Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome

J. A. Watson, R. Pantier, U. Jayachandran, K. Chhatbar, B. Alexander-Howden, V. Kruusvee, M. Prendecki, A. P. Bird, A. G. Cook

This study presents the crystal structure of SALL4 zinc fingers bound to AT-rich DNA, showing flexible recognition and links to Okihiro syndrome mutations.

bioRxiv · Jun 14, 2022Biochemistry

Modulation of RNA binding properties of the RNA helicase UPF1 by its activator UPF2

G. Xue, V. D. Maciej, A. Machado de Amorim, M. Pak, U. Jayachandran, S. Chakrabarti

This study shows that UPF2 binding reduces UPF1's RNA affinity, causing RNA release through an allosteric effect rather than direct competition.

bioRxiv · Mar 26, 2022Biochemistry

Yeast Ssd1 is a non-enzymatic member of the RNase II family with an alternative RNA recognition interface

R. A. Bayne, U. Jayachandran, A. Kasprowicz, S. Bresson, D. Tollervey, E. W. J. Wallace, A. G. Cook

This study identifies the RNA binding interface of Ssd1, a non-catalytic RNase II family member, revealing its preference for 5UTRs of cell wall protein mRNAs and a conserved bipartite motif.

bioRxiv · Oct 22, 2020Biochemistry